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Official Canadian Paediatric Society document (2024) on “Cow’s milk protein allergy in infants and children”. Cow’s milk protein allergy (CMPA) is an immune-mediated reaction to cow’s milk proteins, which can involve multiple organ systems including the gastrointestinal tract. Immunoglobulin E (IgE)-mediated response results in rapid onset of allergic symptoms that are easily recognizable. However, delayed (i.e., non-IgE/cell-mediated), or mixed (IgE- and cell-mediated) reactions produce a host of symptoms that overlap with.
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